Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells.
Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells.
Auteurs : Frances T. Lee [États-Unis] ; Anil Dangi [États-Unis] ; Sahil Shah ; Melanie Burnette [États-Unis] ; Yong-Guang Yang [États-Unis] ; Allan D. Kirk [États-Unis] ; Bernhard J. Hering [États-Unis] ; Stephen D. Miller [États-Unis] ; Xunrong Luo [États-Unis]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
Abstract
Xenogeneic porcine islet transplantation is a promising potential therapy for type 1 diabetes (T1D). Understanding human immune responses against porcine islets is crucial for the design of optimal immunomodulatory regimens for effective control of xenogeneic rejection of porcine islets in humans. Humanized mice are a valuable tool for studying human immune responses and therefore present an attractive alternative to human subject research. Here, by using a pig-to-humanized mouse model of xenogeneic islet transplantation, we described the human immune response to transplanted porcine islets, a process characterized by dense islet xenograft infiltration of human CD45+ cells comprising activated human B cells, CD4+ CD44+ IL-17+ Th17 cells, and CD68+ macrophages. In addition, we tested an experimental immunomodulatory regimen in promoting long-term islet xenograft survival, a triple therapy consisting of donor splenocytes treated with ethylcarbodiimide (ECDI-SP), and peri-transplant rituximab and rapamycin. We observed that the triple therapy effectively inhibited graft infiltration of T and B cells as well as macrophages, promoted transitional B cells both in the periphery and in the islet xenografts, and provided a superior islet xenograft protection. Our study therefore indicates an advantage of donor ECDI-SP treatment in controlling human immune cells in promoting long-term islet xenograft survival.
DOI: 10.1111/ajt.15763
PubMed: 31883299
PubMed Central: PMC7286695
Affiliations:
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Lee</name><affiliation wicri:level="2"><nlm:affiliation>Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Dangi, Anil" sort="Dangi, Anil" uniqKey="Dangi A" first="Anil" last="Dangi">Anil Dangi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Shah, Sahil" sort="Shah, Sahil" uniqKey="Shah S" first="Sahil" last="Shah">Sahil Shah</name><affiliation><nlm:affiliation>Department of Biomedical Engineering, Northwestern University, Evanston, Ilinois.</nlm:affiliation><wicri:noCountry code="subField">Ilinois</wicri:noCountry></affiliation></author><author><name sortKey="Burnette, Melanie" sort="Burnette, Melanie" uniqKey="Burnette M" first="Melanie" last="Burnette">Melanie Burnette</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Yong Guang" sort="Yang, Yong Guang" uniqKey="Yang Y" first="Yong-Guang" last="Yang">Yong-Guang Yang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Columbia University Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kirk, Allan D" sort="Kirk, Allan D" uniqKey="Kirk A" first="Allan D" last="Kirk">Allan D. Kirk</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Surgery, Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Hering, Bernhard J" sort="Hering, Bernhard J" uniqKey="Hering B" first="Bernhard J" last="Hering">Bernhard J. Hering</name><affiliation wicri:level="2"><nlm:affiliation>Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Schulze Diabetes Institute, University of Minnesota, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Miller, Stephen D" sort="Miller, Stephen D" uniqKey="Miller S" first="Stephen D" last="Miller">Stephen D. Miller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Microbiology-Immunology, Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Luo, Xunrong" sort="Luo, Xunrong" uniqKey="Luo X" first="Xunrong" last="Luo">Xunrong Luo</name><affiliation wicri:level="2"><nlm:affiliation>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Duke University School of Medicine, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Surgery, Duke University School of Medicine, Durham</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Xenogeneic porcine islet transplantation is a promising potential therapy for type 1 diabetes (T1D). Understanding human immune responses against porcine islets is crucial for the design of optimal immunomodulatory regimens for effective control of xenogeneic rejection of porcine islets in humans. Humanized mice are a valuable tool for studying human immune responses and therefore present an attractive alternative to human subject research. Here, by using a pig-to-humanized mouse model of xenogeneic islet transplantation, we described the human immune response to transplanted porcine islets, a process characterized by dense islet xenograft infiltration of human CD45<sup>+</sup> cells comprising activated human B cells, CD4<sup>+</sup> CD44<sup>+</sup> IL-17<sup>+</sup> Th17 cells, and CD68<sup>+</sup> macrophages. In addition, we tested an experimental immunomodulatory regimen in promoting long-term islet xenograft survival, a triple therapy consisting of donor splenocytes treated with ethylcarbodiimide (ECDI-SP), and peri-transplant rituximab and rapamycin. We observed that the triple therapy effectively inhibited graft infiltration of T and B cells as well as macrophages, promoted transitional B cells both in the periphery and in the islet xenografts, and provided a superior islet xenograft protection. Our study therefore indicates an advantage of donor ECDI-SP treatment in controlling human immune cells in promoting long-term islet xenograft survival.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31883299</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>06</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>Rejection of xenogeneic porcine islets in humanized mice is characterized by graft-infiltrating Th17 cells and activated B cells.</ArticleTitle><Pagination><MedlinePgn>1538-1550</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.15763</ELocationID><Abstract><AbstractText>Xenogeneic porcine islet transplantation is a promising potential therapy for type 1 diabetes (T1D). Understanding human immune responses against porcine islets is crucial for the design of optimal immunomodulatory regimens for effective control of xenogeneic rejection of porcine islets in humans. Humanized mice are a valuable tool for studying human immune responses and therefore present an attractive alternative to human subject research. Here, by using a pig-to-humanized mouse model of xenogeneic islet transplantation, we described the human immune response to transplanted porcine islets, a process characterized by dense islet xenograft infiltration of human CD45<sup>+</sup> cells comprising activated human B cells, CD4<sup>+</sup> CD44<sup>+</sup> IL-17<sup>+</sup> Th17 cells, and CD68<sup>+</sup> macrophages. In addition, we tested an experimental immunomodulatory regimen in promoting long-term islet xenograft survival, a triple therapy consisting of donor splenocytes treated with ethylcarbodiimide (ECDI-SP), and peri-transplant rituximab and rapamycin. We observed that the triple therapy effectively inhibited graft infiltration of T and B cells as well as macrophages, promoted transitional B cells both in the periphery and in the islet xenografts, and provided a superior islet xenograft protection. Our study therefore indicates an advantage of donor ECDI-SP treatment in controlling human immune cells in promoting long-term islet xenograft survival.</AbstractText><CopyrightInformation>© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Frances T</ForeName><Initials>FT</Initials><Identifier Source="ORCID">0000-0002-6065-0967</Identifier><AffiliationInfo><Affiliation>Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dangi</LastName><ForeName>Anil</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Sahil</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biomedical Engineering, Northwestern University, Evanston, Ilinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burnette</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Yong-Guang</ForeName><Initials>YG</Initials><AffiliationInfo><Affiliation>Department of Medicine, Columbia University Medical Center, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirk</LastName><ForeName>Allan D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Department of Surgery, Duke University School of Medicine, Durham, North Carolina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hering</LastName><ForeName>Bernhard J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Schulze Diabetes Institute, University of Minnesota, Minneapolis, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Stephen D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Xunrong</ForeName><Initials>X</Initials><Identifier Source="ORCID">0000-0001-5581-9409</Identifier><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Surgery, Duke University School of Medicine, Durham, North Carolina.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 EB013198</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI102463</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">basic (laboratory) research/science</Keyword><Keyword MajorTopicYN="Y">immunosuppression/immune modulation</Keyword><Keyword MajorTopicYN="Y">islet transplantation</Keyword><Keyword MajorTopicYN="Y">rejection</Keyword><Keyword MajorTopicYN="Y">tolerance</Keyword><Keyword MajorTopicYN="Y">xenoantigen</Keyword><Keyword MajorTopicYN="Y">xenotransplantation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>11</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2020</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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IdType="pubmed">24427159</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2007 Feb;7(2):402-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17241113</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1993 Feb 1;150(3):1093-104</Citation><ArticleIdList><ArticleId IdType="pubmed">8423334</ArticleId></ArticleIdList></Reference><Reference><Citation>Xenotransplantation. 2016 Jul;23(4):300-9</Citation><ArticleIdList><ArticleId IdType="pubmed">27387829</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2009 May 15;182(10):5982-93</Citation><ArticleIdList><ArticleId IdType="pubmed">19414749</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2013 Sep 1;191(5):2780-2795</Citation><ArticleIdList><ArticleId IdType="pubmed">23918988</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Organ Transplant. 2017 Oct;22(5):452-462</Citation><ArticleIdList><ArticleId IdType="pubmed">28759462</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2015 Jul;15(7):441-51</Citation><ArticleIdList><ArticleId IdType="pubmed">26065586</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Nov;82(22):10964-74</Citation><ArticleIdList><ArticleId IdType="pubmed">18786989</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2013 Oct;174(1):53-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23731328</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2019 Aug;19(8):2155-2163</Citation><ArticleIdList><ArticleId IdType="pubmed">30803121</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2010 Jun;120(6):1836-47</Citation><ArticleIdList><ArticleId IdType="pubmed">20501946</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplant Proc. 2018 Dec;50(10):3900-3905</Citation><ArticleIdList><ArticleId IdType="pubmed">30577284</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1987 May 1;138(9):2848-56</Citation><ArticleIdList><ArticleId IdType="pubmed">2952725</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Transplant. 2017 Jun 9;26(6):925-947</Citation><ArticleIdList><ArticleId IdType="pubmed">28155815</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2014 Jan;14(1):144-55</Citation><ArticleIdList><ArticleId IdType="pubmed">24354874</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2015 Nov;15(11):2837-50</Citation><ArticleIdList><ArticleId IdType="pubmed">26096041</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Immunopharmacol. 2019 Jan;66:274-281</Citation><ArticleIdList><ArticleId IdType="pubmed">30502648</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Mol Biol. 2014;1190:243-55</Citation><ArticleIdList><ArticleId IdType="pubmed">25015285</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2012 Jun;61(6):1527-32</Citation><ArticleIdList><ArticleId IdType="pubmed">22522620</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Immunol Ther Exp (Warsz). 2018 Aug;66(4):245-266</Citation><ArticleIdList><ArticleId IdType="pubmed">29411049</ArticleId></ArticleIdList></Reference><Reference><Citation>Ther Apher Dial. 2017 Apr;21(2):139-149</Citation><ArticleIdList><ArticleId IdType="pubmed">28296027</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Immunol. 2005 Mar;26(3):136-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15745855</ArticleId></ArticleIdList></Reference><Reference><Citation>Xenotransplantation. 2003 Mar;10(2):98-106</Citation><ArticleIdList><ArticleId IdType="pubmed">12588643</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2014 Jul;177(1):333-40</Citation><ArticleIdList><ArticleId IdType="pubmed">24611883</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2013 Sep;62(9):3143-50</Citation><ArticleIdList><ArticleId IdType="pubmed">23852699</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14527-32</Citation><ArticleIdList><ArticleId IdType="pubmed">18796615</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2017 Jan 10;7:686</Citation><ArticleIdList><ArticleId IdType="pubmed">28119695</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2017 Dec 13;12(12):e0189617</Citation><ArticleIdList><ArticleId IdType="pubmed">29236782</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2012 Jul 15;189(2):804-12</Citation><ArticleIdList><ArticleId IdType="pubmed">22696445</ArticleId></ArticleIdList></Reference><Reference><Citation>Xenotransplantation. 2018 Jan;25(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">29135052</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2017 Jan 2;227:34-40</Citation><ArticleIdList><ArticleId IdType="pubmed">27677465</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Immunol. 2008 Apr;127(1):14-25</Citation><ArticleIdList><ArticleId IdType="pubmed">18191619</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2016 Jan 22;6:20044</Citation><ArticleIdList><ArticleId IdType="pubmed">26795594</ArticleId></ArticleIdList></Reference><Reference><Citation>Transpl Immunol. 2009 Jun;21(2):81-6</Citation><ArticleIdList><ArticleId IdType="pubmed">19427901</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2016 Feb;16(2):389-97</Citation><ArticleIdList><ArticleId IdType="pubmed">26588186</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2019 Mar;19(3):674-685</Citation><ArticleIdList><ArticleId IdType="pubmed">30133807</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 2017 Aug;101(8):1801-1810</Citation><ArticleIdList><ArticleId IdType="pubmed">27893617</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Pathol. 2017 Jan 24;12:187-215</Citation><ArticleIdList><ArticleId IdType="pubmed">27959627</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2005 Jun 1;105(11):4390-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15701725</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2011 Sep;121(9):3645-56</Citation><ArticleIdList><ArticleId IdType="pubmed">21821911</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Diab Rep. 2017 Mar;17(3):14</Citation><ArticleIdList><ArticleId IdType="pubmed">28271465</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2006 Oct;6(10):2418-28</Citation><ArticleIdList><ArticleId IdType="pubmed">16925569</ArticleId></ArticleIdList></Reference><Reference><Citation>Immun Inflamm Dis. 2016 Aug 28;4(4):427-440</Citation><ArticleIdList><ArticleId IdType="pubmed">27980777</ArticleId></ArticleIdList></Reference><Reference><Citation>Xenotransplantation. 2008 Mar-Apr;15(2):129-35</Citation><ArticleIdList><ArticleId IdType="pubmed">18447886</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(5):e35506</Citation><ArticleIdList><ArticleId IdType="pubmed">22567105</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2010 Jul 1;185(1):679-87</Citation><ArticleIdList><ArticleId IdType="pubmed">20511558</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2011 Jan 1;186(1):614-20</Citation><ArticleIdList><ArticleId IdType="pubmed">21084661</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2007 Nov;13(11):1295-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17965721</ArticleId></ArticleIdList></Reference><Reference><Citation>Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Dec;36(12):1134-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22246351</ArticleId></ArticleIdList></Reference><Reference><Citation>Transpl Int. 2014 Apr;27(4):408-15</Citation><ArticleIdList><ArticleId IdType="pubmed">24410777</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunology. 2011 Dec;134(4):419-33</Citation><ArticleIdList><ArticleId IdType="pubmed">22044090</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2016 Dec 02;7:546</Citation><ArticleIdList><ArticleId IdType="pubmed">27994589</ArticleId></ArticleIdList></Reference><Reference><Citation>EBioMedicine. 2016 Oct;12:255-262</Citation><ArticleIdList><ArticleId IdType="pubmed">27592597</ArticleId></ArticleIdList></Reference><Reference><Citation>Cold Spring Harb Perspect Med. 2012 May;2(5):a007757</Citation><ArticleIdList><ArticleId IdType="pubmed">22553498</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Organ Transplant. 2017 Dec;22(6):529-534</Citation><ArticleIdList><ArticleId IdType="pubmed">28915137</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(9):e44664</Citation><ArticleIdList><ArticleId IdType="pubmed">22957096</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2014 Mar 20;40(3):355-66</Citation><ArticleIdList><ArticleId IdType="pubmed">24530058</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2000 Jul 1;165(1):247-55</Citation><ArticleIdList><ArticleId IdType="pubmed">10861058</ArticleId></ArticleIdList></Reference><Reference><Citation>Inflamm Bowel Dis. 2015 Jul;21(7):1652-73</Citation><ArticleIdList><ArticleId IdType="pubmed">26035036</ArticleId></ArticleIdList></Reference><Reference><Citation>Arthritis Rheum. 2006 Aug;54(8):2377-86</Citation><ArticleIdList><ArticleId IdType="pubmed">16869000</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 1994 Nov 19;344(8934):1402-4</Citation><ArticleIdList><ArticleId IdType="pubmed">7968077</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Virol. 2015 Aug;13:75-80</Citation><ArticleIdList><ArticleId IdType="pubmed">26083316</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunology. 2018 May;154(1):50-61</Citation><ArticleIdList><ArticleId IdType="pubmed">29446074</ArticleId></ArticleIdList></Reference><Reference><Citation>Xenotransplantation. 2017 Jan;24(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">28058735</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Illinois</li><li>Minnesota</li><li>État de New York</li></region></list><tree><noCountry><name sortKey="Shah, Sahil" sort="Shah, Sahil" uniqKey="Shah S" first="Sahil" last="Shah">Sahil Shah</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Lee, Frances T" sort="Lee, Frances T" uniqKey="Lee F" first="Frances T" last="Lee">Frances T. 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Miller</name><name sortKey="Yang, Yong Guang" sort="Yang, Yong Guang" uniqKey="Yang Y" first="Yong-Guang" last="Yang">Yong-Guang Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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